If the ejaculate lacks sufficient sperm cells, an effort can be made to extract them either from the epididymis or the testicles. MESA, or microchirurgical epididymal sperm aspiration, is the procedure whereby sperm cells are extracted from the epididymis, while TESE, or testicular sperm extraction, yields them through extraction from the testicles.

Treatment for the male is administered through a Andrologist/Urologist, and the sperm cells thereby gained will be cryopreserved until needed for treatment of the female partner. Both procedures are used in combination with ICSI.